Protogon Research

Chai Discovery builds AI foundation models designed to predict and reprogram biochemical molecular interactions, with the goal of transforming drug discovery into an engineering discipline. The company's founders are researchers who co-invented protein language modeling and developed state-of-the-art protein folding algorithms. Chai Discovery is backed by OpenAI, Thrive Capital, and General Catalyst, and has a partnership with Eli Lilly. The company's core platform - anchored by its Chai-1 and Chai-2 models - predicts and redesigns interactions between biochemical molecules at atomic precision. Key capabilities include drug-like antibody design against challenging targets and the generation of functional GPCR agonists with minimal screening. The platform has reported a success rate of over 85% for computationally designed molecules meeting drug-like properties, a figure that contrasts with the traditional approach of screening millions or billions of protein sequences over years at a cost of billions of dollars. Chai Discovery's technical work spans several domains: Protein language modeling and folding algorithms Computational protein and antibody design GPCR agonist design Biopharma-focused machine learning Computational prediction of biochemical interactions The company focuses on targets traditionally considered undruggable, positioning its platform as a tool capable of addressing therapeutic challenges that conventional methods cannot efficiently reach.

Flowdesk is a regulated digital asset trading and technology firm founded in 2020, offering institutional-grade services across market making, over-the-counter (OTC) trading, and treasury management. The firm is registered as a Digital Asset Service Provider with the Financial Market Authority of France and maintains offices in France, Singapore, and the United States, serving token issuers, exchanges, and financial institutions worldwide. At the core of Flowdesk's offering is a proprietary trading infrastructure platform that integrates over 140 centralized and decentralized exchanges. Built with a compliance-first approach, the platform combines algorithmic trading, proprietary risk management tools, and 24/7/365 market access. Its technical stack spans CEX and DEX integration, derivatives trading, and liquidity provision, with an emphasis on bringing transparency and efficiency to digital asset markets. Flowdesk's service portfolio covers: Market making – liquidity provision for digital asset markets OTC trading – spot and derivatives execution for institutional clients Treasury management – tailored solutions for token issuers and institutions Institutional Credit Desk – capital and credit solutions, the firm's most recently launched offering The firm draws on expertise spanning traditional financial markets and blockchain technology, positioning itself as a full-service counterparty for institutions operating in digital asset markets. Its compliance-first architecture and multi-jurisdictional presence reflect an approach oriented toward regulated, institutional-grade engagement with the sector.

Cboe Global Markets is the world's leading exchange network for derivatives, securities, and digital asset trading solutions. Founded in 1973 as the Chicago Board Options Exchange, Cboe pioneered the first listed options contract in the United States, fundamentally transforming the financial landscape. Today, the company operates a robust portfolio of exchanges across North America, Europe, and Asia-Pacific, offering access to options, futures, cash equities, and foreign exchange markets. Cboe is renowned for creating and maintaining the VIX® Index, the global benchmark for market volatility, which has become an essential tool for investors worldwide. The company's cutting-edge technology powers markets globally through its unified trading platform, delivering real-time data, analytics, and clearing services to market participants. Cboe's commitment to innovation is evident in its continuous development of new products and solutions that help investors manage risk and achieve their financial objectives. With approximately 1,661 employees across offices in Chicago, New York, and international locations, Cboe combines deep market expertise with technological leadership. The company's purpose is to build trusted markets that provide a foundation of confidence, enabling investors to focus on managing risk and building sustainable financial futures.

Bloomreach is revolutionizing ecommerce through its AI-powered Loomi platform, which unifies real-time customer and product data to create limitless personalized shopping experiences. By understanding individual customer intent and connecting that intelligence across every channel - from email and SMS to web search and mobile apps - the company enables brands to deliver magical, memorable interactions that drive measurable business growth. Their autonomous search technology goes beyond keyword matching to truly comprehend what shoppers want, while their conversational shopping agents scale the expertise of the best sales associates to guide customers to perfect purchases instantly. Since 2009, Bloomreach has grown to power 25% of all ecommerce experiences in the US and UK, serving over 1,400 global brands including American Eagle, Pandora, and Red Bull. With 900+ employees worldwide and multiple patents for their AI/ML innovations, they process 250 million searches daily and help marketers execute 100,000 email campaigns every day. Their mission - to drive magical and measurable experiences for people and businesses - has made them the trusted Commerce Experience Cloud for retailers, brands, and B2B companies seeking to break the limits of what's possible in digital commerce.

Sea12 Technologies builds AI-powered workflow orchestration platforms for critical industries, including manufacturing, logistics, construction, and facilities management. Its flagship product, Sea12 Orchestrator, integrates data across enterprises to automate entire departmental workflows end-to-end - going well beyond basic chatbot functionality to eliminate manual data entry and deliver operational efficiency at scale. The platform's technology is built around secure, high-performance backend services and cloud-based workflow execution engines, and its reach extends to millions of people daily. The engineering team brings deep expertise in distributed systems, real-time processing, and large language model (LLM) integration, with talent drawn from leading universities. The core technology stack includes Go, TypeScript, React, PostgreSQL, and Redis. Enterprise partners include Yale, Ritz, Eastern Exterior Wall Systems, and Snap-on. Technical domains: AI workflow orchestration, LLM integration, distributed systems, real-time processing, cloud-based execution Stack: Go, TypeScript, React, PostgreSQL, Redis Industries served: Manufacturing, logistics, construction, facilities management Enterprise partners: Yale, Ritz, Eastern Exterior Wall Systems, Snap-on

Backbase is a fintech company founded in Amsterdam in 2003 that builds an AI-powered Banking Platform - what it describes as an AI-native Banking OS - designed to help financial institutions move away from fragmented legacy systems toward a unified operational layer. The platform integrates channels, microservices, and APIs to orchestrate customer journeys across retail, SME, commercial, private banking, and wealth management, enabling both human teams and AI agents to work together at scale. The platform is used by more than 150 financial institutions across 40+ countries, with over 75 million end users interacting with products built on it. Backbase generates $345.5 million in revenue and employs approximately 2,500 people. In addition to its Amsterdam headquarters, the company maintains regional hubs in Atlanta and Singapore. From an engineering standpoint, the platform is built around a microservices and API architecture with AI and AI agent capabilities integrated at the core. Key technical domains include omnichannel delivery, customer journey orchestration, and the broader Banking OS layer that sits across a financial institution's lines of business.