Sesame

Protogon Research builds autonomous AI systems and deploys them directly into financial markets through proprietary trading. The company's stated mission is to develop the most intelligent AI systems in the world, using trading as a practical testbed for AI that genuinely understands the world - rather than one that simply replicates human behaviour or produces superficial outputs. Its long-term research aim is to chart a path toward superintelligence. The company was founded by Rafael Cosman, a serial entrepreneur who previously co-founded Archblock and the TrueFi DeFi protocol. Protogon Research is backed by Zelda Ventures, OVO, and StartX, and is a member of the NVIDIA Inception Program. Protogon's technical work spans machine learning, AI research, trading, and operations. The company describes its technology as original, proprietary, and defensible, and positions itself deliberately apart from traditional quantitative trading firms: the priority is building lasting, transformative AI systems rather than optimising for short-term trading profits. The team is described as highly technical, with deep expertise across its core domains.

OpenEvidence is an AI-powered medical information platform built for healthcare professionals making clinical decisions at the point of care. Its core product functions as an AI copilot for physicians: clinicians submit clinical questions and receive evidence-based answers, synthesised from trusted medical literature and accompanied by references. The platform is available free to verified U.S. healthcare professionals. The platform has reached considerable scale within the U.S. medical community. More than 40% of U.S. physicians log in daily, and the platform has supported over 100 million AI-powered clinical consultations from doctors and frontline clinicians. OpenEvidence draws on partnerships with leading medical institutions and is designed for use across practice settings, from major hospital systems to rural clinics. The company operates at the intersection of several technical disciplines, including: Natural language processing applied to medical literature Clinical decision support and medical knowledge synthesis HIPAA-compliant health IT infrastructure Evidence-based AI for high-stakes clinical environments OpenEvidence is focused on the United States market and positions itself as a foundational layer for how physicians access and apply medical knowledge in practice.

In 1993, three computer scientists - Jensen Huang, Chris Malachowsky, and Curtis Priem - shared a vision that interactive 3D graphics would become the cornerstone of future computing. They founded NVIDIA with a bold mission to bring 3D graphics to the gaming and multimedia markets. Their breakthrough invention of the GPU in 1999 not only sparked the growth of the PC gaming market but also ignited the modern era of artificial intelligence. From those early days of graphics chips, NVIDIA has evolved into the world leader in accelerated computing. The company pioneered the GPU as a specialized processor that handles complex mathematical calculations in parallel, enabling dramatic advancements in gaming, high-performance computing, and AI. Today, NVIDIA drives innovation across industries - from autonomous vehicles and robotics to healthcare and scientific research - tackling challenges no one else can solve by transforming massive amounts of data into actionable insights and real-time experiences.

Sea12 Technologies builds AI-powered workflow orchestration platforms for critical industries, including manufacturing, logistics, construction, and facilities management. Its flagship product, Sea12 Orchestrator, integrates data across enterprises to automate entire departmental workflows end-to-end - going well beyond basic chatbot functionality to eliminate manual data entry and deliver operational efficiency at scale. The platform's technology is built around secure, high-performance backend services and cloud-based workflow execution engines, and its reach extends to millions of people daily. The engineering team brings deep expertise in distributed systems, real-time processing, and large language model (LLM) integration, with talent drawn from leading universities. The core technology stack includes Go, TypeScript, React, PostgreSQL, and Redis. Enterprise partners include Yale, Ritz, Eastern Exterior Wall Systems, and Snap-on. Technical domains: AI workflow orchestration, LLM integration, distributed systems, real-time processing, cloud-based execution Stack: Go, TypeScript, React, PostgreSQL, Redis Industries served: Manufacturing, logistics, construction, facilities management Enterprise partners: Yale, Ritz, Eastern Exterior Wall Systems, Snap-on

Chai Discovery builds AI foundation models designed to predict and reprogram biochemical molecular interactions, with the goal of transforming drug discovery into an engineering discipline. The company's founders are researchers who co-invented protein language modeling and developed state-of-the-art protein folding algorithms. Chai Discovery is backed by OpenAI, Thrive Capital, and General Catalyst, and has a partnership with Eli Lilly. The company's core platform - anchored by its Chai-1 and Chai-2 models - predicts and redesigns interactions between biochemical molecules at atomic precision. Key capabilities include drug-like antibody design against challenging targets and the generation of functional GPCR agonists with minimal screening. The platform has reported a success rate of over 85% for computationally designed molecules meeting drug-like properties, a figure that contrasts with the traditional approach of screening millions or billions of protein sequences over years at a cost of billions of dollars. Chai Discovery's technical work spans several domains: Protein language modeling and folding algorithms Computational protein and antibody design GPCR agonist design Biopharma-focused machine learning Computational prediction of biochemical interactions The company focuses on targets traditionally considered undruggable, positioning its platform as a tool capable of addressing therapeutic challenges that conventional methods cannot efficiently reach.

Bloomreach is revolutionizing ecommerce through its AI-powered Loomi platform, which unifies real-time customer and product data to create limitless personalized shopping experiences. By understanding individual customer intent and connecting that intelligence across every channel - from email and SMS to web search and mobile apps - the company enables brands to deliver magical, memorable interactions that drive measurable business growth. Their autonomous search technology goes beyond keyword matching to truly comprehend what shoppers want, while their conversational shopping agents scale the expertise of the best sales associates to guide customers to perfect purchases instantly. Since 2009, Bloomreach has grown to power 25% of all ecommerce experiences in the US and UK, serving over 1,400 global brands including American Eagle, Pandora, and Red Bull. With 900+ employees worldwide and multiple patents for their AI/ML innovations, they process 250 million searches daily and help marketers execute 100,000 email campaigns every day. Their mission - to drive magical and measurable experiences for people and businesses - has made them the trusted Commerce Experience Cloud for retailers, brands, and B2B companies seeking to break the limits of what's possible in digital commerce.